National Business

WASHINGTON (AP) — The Supreme Court on Monday refused a request from tobacco companies to stop California from enforcing a ban on flavored tobacco products that was overwhelmingly approved by voters in November. R.J.

CALGARY — Spills from TC Energy Corp.'s Keystone pipeline have been increasing in severity in recent years, to the point that the pipeline's safety record is now worse than the U.S. average, U.S. government data shows.

TORONTO — Constellation Software Inc. says it will buy U.S. tech company WideOrbit Inc., merge the firm with its subsidiary Lumine Group and then spin them off into a separate business.

OTTAWA — Canadian households' debt-to-income ratio rose in the third quarter as rising interest rates affected the cost of borrowing. There was $1.

Microsoft is taking a roughly 4% stake in the operator of the London Stock Exchange, which has agreed to spend at least $2.8 billion in cloud-computing services from the technology giant.

Amgen is spending more than $26 billion to dive deeper into rare disease treatments with a deal for drugmaker Horizon Therapeutics. The biotech drug developer said Monday that it will pay $116.

VANCOUVER — Activist investor Sandpiper Group is seeking to replace four of the nine trustees at First Capital Real Estate Investment Trust, including chair Bernard McDonell.

The heads of the International Energy Agency and European Union's executive branch said Monday that the 27-nation bloc is expected to weather an energy crisis this winter but needs to speed renewables to the market and take other steps to avoid a pot

CALGARY — Pembina Pipeline Corp. has signed a deal to sell Pembina Gas Infrastructure's 50 per cent interest in the Key Access Pipeline System to private equity firm Stonepeak Partners LP for $662.5 million.

NEW YORK (AP) — Twitter is once again attempting to launch its premium service, a month after a previous attempt failed .